Differential Regulation of Unconventional Fission Yeast Myosins via the Actin Track
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چکیده
منابع مشابه
Differential Regulation of Unconventional Fission Yeast Myosins via the Actin Track
BACKGROUND Fission yeast possesses three unconventional myosins: Myo1p (a class I myosin that functions at endocytic actin patches) and Myo51p and Myo52p (class V myosins that function at contractile rings and actin cables, respectively). Here we used a combination of in vivo and in vitro approaches to investigate how changes in the actin track influence the motor activity and spatial regulatio...
متن کاملRegulation and function of the fission yeast myosins.
It is now quarter of a century since the actin cytoskeleton was first described in the fission yeast, Schizosaccharomyces pombe. Since then, a substantial body of research has been undertaken on this tractable model organism, extending our knowledge of the organisation and function of the actomyosin cytoskeleton in fission yeast and eukaryotes in general. Yeast represents one of the simplest eu...
متن کاملUnconventional myosins, actin dynamics and endocytosis: a ménage à trois?
Ever since the discovery of class I myosins, the first nonmuscle myosins, about 30 years ago, the history of unconventional myosins has been linked to the organization and working of actin filaments. It slowly emerged from studies of class I myosins in lower eukaryotes that they are involved in mechanisms of endocytosis. Most interestingly, a flurry of recent findings assign a more active role ...
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1 FUNCTIONAL ADAPTATION BETWEEN YEAST ACTIN AND ITS COGNATE MYOSIN MOTORS Benjamin C. Stark, Kuo-Kuang Wen, John S. Allingham, Peter A. Rubenstein & Matthew Lord* Department of Molecular Physiology & Biophysics, University of Vermont, Burlington, VT 05405, USA Department of Biochemistry, University of Iowa College of Medicine, Iowa City, IA 52242, USA Department of Biochemistry, Queen's Univers...
متن کاملUnconventional myosins acting unconventionally.
Unconventional myosins are proteins that bind actin filaments in an ATP-regulated manner. Because of their association with membranes, they have traditionally been viewed as motors that function primarily to transport membranous organelles along actin filaments. Recently, however, a wealth of roles for myosins that are not obviously related to organelle transport have been uncovered, including ...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2010
ISSN: 0960-9822
DOI: 10.1016/j.cub.2010.07.026